Ninety percent of Big 12 football programs had a player taken in the 2021 NFL Draft for a total of 22 selections. Oklahoma and Texas' five picks each tied for 11th among all schools. Oklahoma State was close behind with four selections.

Big 12 Players in the 2021 NFL Draft
Second Round
39. Teven Jenkins, OL (Oklahoma State), Chicago Bears
43. Trevon Moehrig, DB (TCU), Las Vegas Raiders
51. Sam Cosmi, OT (Texas), Washington Football Team
63. Creed Humphrey, C (Oklahoma), Kansas City Chiefs
 
Third Round
69. Joseph Ossai, DE (Texas), Cincinnati Bengals
96. Ronnie Perkins, DE (Oklahoma), New England Patriots
 
Fourth Round
119. Kene Nwangwu, RB (Iowa State), Minnesota Vikings
120. Rhamondre Stevenson, RB (Oklahoma), New England Patriots
123. Zech McPhearson, DB (Texas Tech), Philadelphia Eagles
126. Chuba Hubbard, RB (Oklahoma State), Carolina Panthers
131. Tylan Wallace, WR (Oklahoma State), Baltimore Ravens
137. Tre Brown, DB (Oklahoma), Seattle Seahawks
 
Fifth Round
148. Ta’Quon Graham, DT (Texas), Atlanta Falcons
152. Caden Sterns, DB (Texas), Denver Broncos
153. Tony Fields II, LB (West Virginia), Cleveland Browns
170. Garret Wallow, LB (TCU), Houston Texans
 
Sixth Round
201. Rodarius Williams, DB (Oklahoma State), New York Giants
218. Sam Ehlinger, QB (Texas), Indianapolis Colts
235. Wyatt Hubert, DE (Kansas State), Cincinnati Bengals
236. Jack Anderson, OL (Texas Tech), Buffalo Bills
240. Will Bradley-King, DE (Baylor), Washington Football Team
245. Tre Norwood, DB (Oklahoma), Pittsburgh Steelers