The Big 12 had 25 players selected in the 2022 NFL Draft, its most since 26 in 2019, and tied with the Pac-12 for the third-most draftees among conferences.

Oklahoma’s seven selections tied with Alabama for fifth-most among institutions. Baylor's six picks  tied a program record for selections in a seven-round draft while Iowa State's four draftees are its most in a seven-round draft. Cyclone RB Breece Hall was the first Big 12 player chosen as the No. 36 overall selection in the second round by the New York Jets.

Second Round
36. Breece Hall, RB (Iowa State), New York Jets
37. Jalen PItre, S (Baylor), Houston Texans
50. Tyquan Thornton, WR (Baylor), New England Patriots
64. Nik Bonitto, OLB (Oklahoma), Denver Broncos

Third Round
66. Brian Asamoah, ILB (Oklahoma), Minnesota Vikings
79. JT Woods, S (Baylor), Los Angeles Chargers
89. Terrel Bernard, ILB (Baylor), Buffalo Bills

Fourth Round
108. Perrion Winfrey, DT (Oklahoma), Cleveland Browns
116. Eyioma Uwazurike, DE (Iowa State), Denver Broncos
125. Erik Ezukanma, WR (Texas Tech), Miami Dolphins
128. Charlie Kolar, TE (Iowa State), Baltimore Ravens

Fifth Round
152. Delarrin Turner-Yell, S (Oklahoma), Denver Broncos

Sixth Round
181. Kyron Johnson, ILB (Kansas), Philadelphia Eagles
188. Malcolm Rodriguez, ILB (Oklahoma State), Detroit Lions
193. Devin Harper, ILB (Oklahoma State), Dallas Cowboys
202. Michael Woods II, WR (Oklahoma), Cleveland Browns
203. Trestan Ebner, RB (Baylor), Chicago Bears

Seventh Round
223. Isaiah Thomas, DE (Oklahoma), Cleveland Browns
240. Christian Holmes, CB (Oklahoma State), Washington Commanders
242. Kalon Barnes, CB (Baylor), Carolina Panthers
246. Dawson Deaton, C (Texas Tech), Cleveland Browns
247. Skylar Thompson, QB (K-State), Miami Dolphins
253. Russ Yeast, S (K-State), Los Angeles Rams
257. Marquis Hayes, OL (Oklahoma), Arizona Cardinals
262. Brock Purdy, QB (Iowa State), San Francisco 49ers